Original Articles

Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame

Y. Pat, D. Yazici, C. Zeyneloglu, et al.

Cannabinoid WIN55,212-2 restores bronchial epithelium by regulating oxidative stress and STAT6 phosphorylation

Pérez-Diego M, Angelina A, Pat Y, et al.

Immune impacts of fire smoke exposure

Johnson MM, Kaushik A, Kline OA, et al.

Maternal stress triggers early-life eczema through fetal mast cell programming

Serhan, N., Abdullah, N.S., Gheziel, N. et al.

Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis

P. D'Avino, J. Kim, M. Li, et al.

IL-37 protects against house dust mite-induced airway inflammation and airway epithelial barrier dysfunction via inhibiting store-operated calcium entry.

Wang C, Zhong J, Hu J, et al.

Direct assessment of skin epithelial barrier by electrical impedance spectroscopy

Rinaldi AO, Morita H, Wawrzyniak P, et al.

Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis

Rinaldi AO, Korsfeldt A, Ward S et al.

Gut epithelial barrier damage caused by dishwasher detergents and rinse aids

Ogulur I, Pat Y, Aydin T, et al.

Spatial transcriptomics combined with single-cell RNA-sequencing unravels the complex inflammatory cell network in atopic dermatitis

Mitamura Y, Reiger M, Kim J,

Disrupted epithelial permeability as a predictor of severe COVID-19 development.

Yazici D, Cagan E, Tan G, et al.

Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80

Ogulur I, Yazici D, Pat Y, et al.

The Epithelial Barrier Theory is a comprehensive explanation for the global, epidemic-level rise in chronic health conditions over the past 65 years. The theory, postulated by Akdis, proposes that exposure to toxic substances introduced by industrialization and modern lifestyle changes disrupts the epithelial barrier of the skin, upper and lower airways, and gut mucosa and causes microbial dysbiosis triggering an inflammatory immune response that can initiate or aggravate many chronic inflammatory diseases.